The luteal phase after GnRH-agonist triggering of ovulation: present and future perspectives

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The luteal phase after GnRH-agonist triggering of ovulation: present and future perspectives.

In stimulated IVF/intracytoplasmic sperm injection cycles, the luteal phase is disrupted, necessitating luteal-phase supplementation. The most plausible reason behind this is the ovarian multifollicular development obtained after ovarian stimulation, resulting in supraphysiological steroid concentrations and consecutive inhibition of LH secretion by the pituitary via negative feedback at the le...

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I-27: GnRH Agonist Triggering and Luteal Phase Support

Background GnRH agonist triggering is one of the strategies for ovulation triggering and final maturation of oocytes. So , should be notice for luteal phase support in these cycles. At the first it was began for prevention of severe OHSS but it was associated with luteal phase problem and lower pregnancy rate due to luteolysis effects of GnRH agonists. So, two other alternative strategies have ...

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Luteal phase support after GnRH triggering in IVF cycles

Corespondență: Dr. Andreea Carp Velișcu e-mail: andreea_veliscu@ yahoo.com Introduction. The luteal phase in IVF stimulated cycles is very different from that in natural cycles, so is very important to mimic the perfect condition for pregnancy. Method. Since January 2015 until December 2015, we have 88 cycles in which the triggering was done with GnRH agonist. We performed an embriotransfer in ...

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Ovulation triggering with GnRH agonists

Ovarian hyperstimulation syndrome (OHSS) remains a major complication of IVF. Triggering ovulation with human chorionic gonadotrophin (HCG) (as a surrogate to LH) is a major factor in the initiation of OHSS. The pathological process usually intensifies if pregnancy is achieved, as the rising endogenous HCG overstimulates the corpora lutea. Decreasing HCG trigger dose does not prevent OHSS. Gona...

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GnRH agonist ovulation trigger and hCG-based, progesterone-free luteal support: a proof of concept study.

BACKGROUND It is now well established that a GnRH agonist (GnRHa) ovulation trigger completely prevents ovarian hyperstimulation syndrome. However, early studies, using conventional luteal support, showed inferior clinical results following a GnRHa trigger compared with a conventional hCG trigger in normal responder IVF patients. We here present a novel approach for luteal support after a GnRHa...

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ژورنال

عنوان ژورنال: Reproductive BioMedicine Online

سال: 2012

ISSN: 1472-6483

DOI: 10.1016/j.rbmo.2011.11.001